Bone Abstracts

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Vitamin D deficiency is common in aging people and is associated with secondary hyperparathyroidism, bone loss, osteoporosis and fractures in epidemiological studies. Vitamin D3 is produced in the skin through u.v. irradiation of the sun in spring and summer, and it can also be obtained from food, especially fatty fish, such as herring or mackerel. Vitamin D is activated by liver and kidney. Its main action is stimulation of calcium absorption from the gut. Vitamin ...

Vitamin D deficiency is common in older persons and non-western immigrants. Vitamin D is often started in loading doses of 50 000 IU/ml solution. Though, generally considered safe, this highly concentrated solution carries some risks as is illustrated by the following cases. A woman of >80 years old was admitted with hypercalcemia, calcium 3.27 mmol/l. She complained of nausea, thirst and polyuria for 3 months. History included cholecystitis, atrial fibrillation, myocardia...

Introduction: Vitamin D deficiency has been associated with impaired physical functioning and several chronic diseases and might thereby affect quality of life and self-rated health. The aim of this study was to assess relationships of serum 25-hydroxyvitamin D (25(OH)D) with quality of life and self-rated health, and to examine whether physical performance and number of chronic diseases mediate these relationships.Methods: Data were obtained from the LA...

Introduction: Measures of physical function may be related to osteoporosis and fractures in older individuals and may thus be used in the identification of individuals at high fracture risk.Aim: The aim of this study was to investigate which measures of physical functioning are associated with bone quality and fracture incidence and whether gender-specific differences exist within these associations.Methods: We studied 1486 partici...

Fracture outpatient (FO) clinics aim to identify individuals at high fracture risk. Identification of individuals at high fracture risk has been improved since the introduction of vertebral fracture assessment (VFA). Unfortunately, participation rates in FO clinics are often low.The aim of this study is to i) assess the contributory value of VFA in addition to BMD measurements in identifying individuals with high fracture risk; ii) assess characteristics...

Objective: Increase the percentage of elderly fracture patients undergoing a dual energy X-ray absorptiometry (DXA) measurement, and investigate why some patients did not respond to invitation to our fracture liaison service (FLS).Materials and methods: In four Dutch hospitals, fracture patients ≥50 years were invited for a DXA measurement and visit to our FLS. Patients who did not respond, were contacted by telephone. In patients diagnosed with os...

Vitamin D deficiency is common within Europe and the Middle East, especially in risk groups. While treatment is simple, there is no consensus on the diagnostic threshold for deficiency and the required dose. The Institute of Medicine and the Endocrine Society have established guidelines on the required 25-hydroxyvitamin D (25(OH)D) levels, supplementation doses and (extra)skeletal effects of vitamin D, coming to very different conclusions. The European Calcified Tissue Society...